Hoon Hay residents are angry at mental health patients who "crawl in the street" for cigarette butts, rummage through rubbish bins, defecate in public and verbally abuse locals.
The patients live at private facility Hoon Hay House, in Anvers Place, which caters for people who require specialist mental health care and are allowed offsite.
Residents and local business owners will meet with their local MP, Labour's Megan Woods, next week to discuss the patients' behaviour.
Tankerville Rd resident Pauline King said trouble began when the facility, owned by the Golden Healthcare Group, was established in 2011.
"I've been here for 33 years and I haven't seen anything like it."
King claimed items, including a school bag, playset mirror and a ride-on toy had been taken from her section by Hoon Hay House patients.
Her daughter, Kerry-Anne, said she had contacted Hoon Hay House more than 10 times in the last six years to report patient behaviour, but management "haven't done anything about it".
"It's not just for our safety but for the patients' safety too," King said.
Anvers Place resident Sue Henry said three female patients sat outside the Coppell Place shops and begged for money.
"If you cross the road they will follow you and beg for money," she said. "It's a daily occurrence now.
"There are little kids up at the shops unsupervised," Henry said. "What if the patients get abusive with them?
"The staff need to take a serious look at how patients are supervised."
Residents said the patients' behaviour was ``extreme'' and they should be supervised on outings.