From November 30 the airline will fly to the Windy City three times weekly.
Air New Zealand CEO Christopher Luxon says the addition of Chicago to the network will be an attractive option for kiwis wanting to explore the city and North America.
"As well as being great for travellers, this new route is good news for New Zealand, as we expect it to contribute (NZD) $70 million annually to our economy," Luxon said.
The flight is expected to take between 15 and 16 hours.
The new route will provide New Zealanders with greater opportunity to travel to the United State as United airline connects to over 100 destinations in America.
Air New Zealand also announced that its Auckland to San Francisco route will operate year-round from April 2019.
United's International Network Vice President Patrick Quayle said that the connections between Air New Zealand and United Airways will benefit New Zealanders wanting to travel around America.
"Today's announcements are great examples of the customer benefits that result from the strong, strategic alliance and partnership between United Airways and Air New Zealand," Quayle said.